Cody Brown’s

NFL BETTING GUIDE

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SAN FRANCISCO 49ERS player in helmet

SAN FRANCISCO 49ERS

OVERVIEW

I’m a little torn on the Niners this season. They have a great roster and are well coached but they have been dealing with some serious injury issues over the last few seasons. The electrical substation stuff is crazy to me bit there is no denying they’ve got some sort of injury curse. San Francisco's offense ranked third in success rate and sixth in points per drive last season despite Brock Purdy missing eight total games to injury, and George Kittle, Ricky Pearsall, and Jauan Jennings all missing significant time too. The front office responded by replacing Jennings with six-time Pro Bowler Mike Evans, signed to a genuinely team-friendly contract this offseason. The 49ers were one of four teams with a perfect win percentage when leading at halftime last season.

Head Coach

KYLE SHANAHAN

Offensive Coordinator

KLAY KUBIAK

Defensive Coordinator

RAHEEM MORRIS

OFF SEASON CHANGES

The big story throughout the off-season for the Niners has been their injuries. Wide Receiver Ricky Pearsall will miss the entire season after having surgery on a PCL injury that he sustained last year. It’s crazy to me that they didn’t operate on it earlier and when he arrived at training camp he was not healthy. The Niners signed future hall of famer Mike Evans but he has also been dealing with a quad strain and sat out parts of training camp. They brought back Deebo Samuel after he had a year in Washington and he’s now essential depth. WR Brandon Aiyuk is technically still with the Niners but he won’t play with them again.

QUATERBACKS

Brock Purdy ranks second in the NFL in passer rating among quarterbacks with 1,000-plus attempts since 2022 and when healthy in 2025 he completed 70.6% of his passes for a 7.6% touchdown rate, both elite marks even in a season limited to nine total games. He has his doubters but is definitely one of the more reliable quarterbacks in the league when healthy. Mike Evans is going to give him a really nice end zone option to complement Christian McCaffrey on the ground. Purdy’s passing touchdowns line is set for 27.5 this season which I think looks a little high. Yes, he has Evans and Deebo Samuel back, but he’s only gone above that number once in his four NFL seasons.

RUNNING BACKS

Christian McCaffrey returns for his 11th NFL season and looks as fit as ever. He did have some regression last season in terms of yards per carry, averaging just 3.9 YPC, his lowest mark since his first NFL season. A lot of that came down to some offensive line troubles and other health issues. I actually think despite his age he can improve that efficiency this season. His pass catching numbers are unbelievable, recording 102 receptions as a running back last year. He can do it all and I expect another productive season for him if he remains healthy.

RECEIVERS

If healthy, this wide receiving corps would be one of the best in the league. Unfortunately that’s not the case. Ricky Pearsall will miss the entire season through injury and new signing Mike Evans is also dealing with a quad strain. The Niners hope he’ll be ready for Week 1 though. Jauan Jennings was a sizeable loss but they replaced him with Deebo Samuel who returns for a second stint in San Francisco. The big one that the Niners are most excited about, and reliant on, is rookie WR De’Zhaun Stribling. He was taken with pick 33 and Niners beat reporters say he looks really good in camp. George Kittle remains an elite tight end but is coming off a torn achilles and he isn’t getting any younger. He should be ready to go Week 1 but whether he can get back to his best remains to be seen. San Francisco's offense ranked third in success rate and sixth in points per drive last season even without player health, so there’s definitely upside with Purdy under center.

DEFENCE

Nick Bosa remains one of the NFL's premier edge defenders, and the front office added interior disruptor Osa Odighizuwa via trade to take pressure off him, while Fred Warner continues to anchor one of the league's smartest linebacker units. San Francisco was 28th in defensive player health last season, with Bosa suffering a season-ending injury in Week 3 and Warner playing just six games — better health alone could be a massive defensive upgrade.

PREDICTIONS

10-7

If healthy, this team is a real playoff contender. Unfortunately there is just too much unknown for me to give them a better record. Christian McCaffrey, Brock Purdy, Mike Evans and co give them a great offensive core but all of them have injury history. This division is incredibly tough as well with the Rams and Seahawks to play twice.

SAN FRANCISCO 49ERS star player in uniform

FAVORITE FUTURE

MIKE EVANS OVER 6.5 RECEIVING TDS

I think Evans will be a huge red zone threat for the Niners this year. He might not get his usual 1000+ yardage season but he will be on the field in red zone scenarios and that’s the type of receiver the Niners have been missing. Purdy is capable of putting up 30+ passing TDs in a season and Evans should haul in at least seven of those. He has 7+ receiving TDs in 7 NFL seasons already.

Fanduel Lines

Win Total
9.5
Make Playoffs
-136
Miss Playoffs
+116
Win Superbowl
+1800
Win Conference
+900
Win Division
+340

SCHEDULE

LAR

WK 1 Away

Difficult

DAL

WK 10 Away

Moderate

MIA

WK 2 Home

Easy

MIN

WK 11 Home

Moderate

ARI

WK 3 Home

Easy

SEA

WK 12 Home

Difficult

DEN

WK 4 Home

Moderate

NYG

WK 13 Away

Easy

SEA

WK 5 Away

Difficult

LAR

WK 14 Home

Difficult

WAS

WK 6 Home

Easy

LAC

WK 15 Away

Difficult

ATL

WK 7 Away

Easy

KC

WK 16 Away

Difficult

NO GAME

WK 8

PHI

WK 17 Home

Difficult

LV

WK 9 Home

Easy

ARI

WK 18 Away

Easy

LAR

WK 1 Away

Difficult

ATL

WK 7 Away

Easy

NYG

WK 13 Away

Easy

MIA

WK 2 Home

Easy

NO GAME

WK 8

LAR

WK 14 Home

Difficult

ARI

WK 3 Home

Easy

LV

WK 9 Home

Easy

LAC

WK 15 Away

Difficult

DEN

WK 4 Home

Moderate

DAL

WK 10 Away

Moderate

KC

WK 16 Away

Difficult

SEA

WK 5 Away

Difficult

MIN

WK 11 Home

Moderate

PHI

WK 17 Home

Difficult

WAS

WK 6 Home

Easy

SEA

WK 12 Home

Difficult

ARI

WK 18 Away

Easy

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